Protein kinase A controls the hexosamine pathway by tuning the feedback inhibition of GFAT-1

The hexosamine pathway (HP) is a key anabolic pathway whose product uridine 5’-diphospho-N-acetyl-D-glucosamine (UDP-GlcNAc) is an essential precursor for glycosylation processes in mammals. It modulates the ER stress response and HP activation extends lifespan in Caenorhabditis elegans. The highly...

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Detalles Bibliográficos
Autores principales: Ruegenberg, Sabine, Mayr, Felix A. M. C., Atanassov, Ilian, Baumann, Ulrich, Denzel, Martin S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8041777/
https://www.ncbi.nlm.nih.gov/pubmed/33846315
http://dx.doi.org/10.1038/s41467-021-22320-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8041777/
https://www.ncbi.nlm.nih.gov/pubmed/33846315
http://dx.doi.org/10.1038/s41467-021-22320-y

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