Reduced IQGAP2 expression promotes EMT and inhibits apoptosis by modulating the MEK-ERK and p38 signaling in breast cancer irrespective of ER status

IQGAP2, a member of the IQGAP family, functions as a tumor suppressor in most of the cancers. Unlike IQGAP1 and IQGAP3, which function as oncogenes in breast cancer, the role of IQGAP2 is still unexplored. Here we report a reduced expression of IQGAP2, which was associated with lymph node positivity...

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Detalles Bibliográficos
Autores principales: Kumar, Dinesh, Patel, Saket Awadesbhai, Hassan, Md. Khurshidul, Mohapatra, Nachiketa, Pattanaik, Niharika, Dixit, Manjusha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8041781/
https://www.ncbi.nlm.nih.gov/pubmed/33846302
http://dx.doi.org/10.1038/s41419-021-03673-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8041781/
https://www.ncbi.nlm.nih.gov/pubmed/33846302
http://dx.doi.org/10.1038/s41419-021-03673-0

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