Simvastatin accelerated motoneurons death in SOD1(G93A) mice through inhibiting Rab7-mediated maturation of late autophagic vacuoles

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease caused by motoneuron loss, for which there is currently no effective treatment. Statins, as inhibitors of 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase, are used as drugs for treatment for a variety of disease such a...

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Detalles Bibliográficos
Autores principales: Bai, Lin, Wang, Yafei, Huo, Jia, Li, Shuai, Wen, Ya, Liu, Qi, Yang, Jing, Liu, Yaling, Li, Rui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8041862/
https://www.ncbi.nlm.nih.gov/pubmed/33846297
http://dx.doi.org/10.1038/s41419-021-03669-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8041862/
https://www.ncbi.nlm.nih.gov/pubmed/33846297
http://dx.doi.org/10.1038/s41419-021-03669-w

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