Coexistence of inhibitory and activating killer-cell immunoglobulin-like receptors to the same cognate HLA-C2 and Bw4 ligands confer breast cancer risk

Human leukocyte antigen (HLA) class I-specific killer-cell immunoglobulin-like receptors (KIR) regulate natural killer (NK) cell function in eliminating malignancy. Breast cancer (BC) patients exhibit reduced NK-cytotoxicity in peripheral blood. To test the hypothesis that certain KIR-HLA combinatio...

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Detalles Bibliográficos
Autores principales: Ashouri, Elham, Rajalingam, Karan, Barani, Shaghik, Farjadian, Shirin, Ghaderi, Abbas, Rajalingam, Raja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8041876/
https://www.ncbi.nlm.nih.gov/pubmed/33846431
http://dx.doi.org/10.1038/s41598-021-86964-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8041876/
https://www.ncbi.nlm.nih.gov/pubmed/33846431
http://dx.doi.org/10.1038/s41598-021-86964-y

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