An engineered channelrhodopsin optimized for axon terminal activation and circuit mapping

Optogenetic tools such as channelrhodopsin-2 (ChR2) enable the manipulation and mapping of neural circuits. However, ChR2 variants selectively transported down a neuron’s long-range axonal projections for precise presynaptic activation remain lacking. As a result, ChR2 activation is often contaminat...

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Detalles Bibliográficos
Autores principales: Hamada, Shun, Nagase, Masashi, Yoshizawa, Tomohiko, Hagiwara, Akari, Isomura, Yoshikazu, Watabe, Ayako M., Ohtsuka, Toshihisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8042110/
https://www.ncbi.nlm.nih.gov/pubmed/33846537
http://dx.doi.org/10.1038/s42003-021-01977-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8042110/
https://www.ncbi.nlm.nih.gov/pubmed/33846537
http://dx.doi.org/10.1038/s42003-021-01977-7

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