Low expression of the PPARγ-regulated gene thioredoxin-interacting protein accompanies human melanoma progression and promotes experimental lung metastases

The thioredoxin system plays key roles in regulating cancer cell malignancy. Here we identify the Thioredoxin-interacting protein (TXNIP) as a gene, which expression is regulated by PPARγ in melanoma cells. We show that high TXNIP expression levels associate with benign melanocytic lesions, with tum...

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Detalles Bibliográficos
Autores principales: Meylan, Patrick, Pich, Christine, Winkler, Carine, Ginster, Stefanie, Mury, Lionel, Sgandurra, Marie, Dreos, René, Frederick, Dennie Tompers, Hammond, Marc, Boland, Genevieve Marie, Michalik, Liliane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8042115/
https://www.ncbi.nlm.nih.gov/pubmed/33846376
http://dx.doi.org/10.1038/s41598-021-86329-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8042115/
https://www.ncbi.nlm.nih.gov/pubmed/33846376
http://dx.doi.org/10.1038/s41598-021-86329-5

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