In silico discovery and evaluation of phytochemicals binding mechanism against human catechol-O-methyltransferase as a putative bioenhancer of L-DOPA therapy in Parkinson disease

Levodopa (L-DOPA) therapy is normally practised to treat motor pattern associated with Parkinson disease (PD). Additionally, several inhibitory drugs such as Entacapone and Opicapone are also cosupplemented to protect peripheral inactivation of exogenous L-DOPA (~80%) that occurs due to metabolic ac...

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Detalles Bibliográficos
Autores principales: Rath, Surya Narayan, Jena, Lingaraja, Bhuyan, Rajabrata, Mahanandia, Nimai Charan, Patri, Manorama
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korea Genome Organization 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8042297/
https://www.ncbi.nlm.nih.gov/pubmed/33840171
http://dx.doi.org/10.5808/gi.20061

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8042297/
https://www.ncbi.nlm.nih.gov/pubmed/33840171
http://dx.doi.org/10.5808/gi.20061

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