Gut Microbiota-Mediated Transformation of Coptisine Into a Novel Metabolite 8-Oxocoptisine: Insight Into Its Superior Anti-Colitis Effect

Coptisine (COP) is a bioactive isoquinoline alkaloid derived from Coptis Chinemsis Franch, which is traditionally applied for the management of colitis. However, the blood concentration of COP was extremely low, and its gut microbiota-mediated metabolites were thought to contribute to its prominent...

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Detalles Bibliográficos
Autores principales: Ai, Gaoxiang, Huang, Ziwei, Cheng, Juanjuan, Xie, Jianhui, Zeng, Huifang, Liu, Yuhong, Li, Yucui, Huang, Xiaoqi, Chen, Jiannan, Su, Ziren
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8042337/
https://www.ncbi.nlm.nih.gov/pubmed/33859564
http://dx.doi.org/10.3389/fphar.2021.639020

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8042337/
https://www.ncbi.nlm.nih.gov/pubmed/33859564
http://dx.doi.org/10.3389/fphar.2021.639020

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