4β-Hydroxycholesterol is a prolipogenic factor that promotes SREBP1c expression and activity through the liver X receptor

Oxysterols are oxidized derivatives of cholesterol that play regulatory roles in lipid biosynthesis and homeostasis. How oxysterol signaling coordinates different lipid classes such as sterols and triglycerides remains incompletely understood. Here, we show that 4β-hydroxycholesterol (HC) (4β-HC), a...

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Detalles Bibliográficos
Autores principales: Moldavski, Ofer, Zushin, Peter-James H., Berdan, Charles A., Van Eijkeren, Robert J., Jiang, Xuntian, Qian, Mingxing, Ory, Daniel S., Covey, Douglas F., Nomura, Daniel K., Stahl, Andreas, Weiss, Ethan J., Zoncu, Roberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8042401/
https://www.ncbi.nlm.nih.gov/pubmed/33631213
http://dx.doi.org/10.1016/j.jlr.2021.100051

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8042401/
https://www.ncbi.nlm.nih.gov/pubmed/33631213
http://dx.doi.org/10.1016/j.jlr.2021.100051

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