PKCα-mediated phosphorylation of the diacylglycerol kinase ζ MARCKS domain switches cell migration modes by regulating interactions with Rac1 and RhoA

Cells can switch between Rac1 (lamellipodia-based) and RhoA (blebbing-based) migration modes, but the molecular mechanisms regulating this shift are not fully understood. Diacylglycerol kinase ζ (DGKζ), which phosphorylates diacylglycerol to yield phosphatidic acid, forms independent complexes with...

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Detalles Bibliográficos
Autores principales: Ard, Ryan, Maillet, Jean-Christian, Daher, Elias, Phan, Michael, Zinoviev, Radoslav, Parks, Robin J., Gee, Stephen H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8042443/
https://www.ncbi.nlm.nih.gov/pubmed/33676892
http://dx.doi.org/10.1016/j.jbc.2021.100516

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8042443/
https://www.ncbi.nlm.nih.gov/pubmed/33676892
http://dx.doi.org/10.1016/j.jbc.2021.100516

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