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Loss of mitochondrial aconitase promotes colorectal cancer progression via SCD1-mediated lipid remodeling
OBJECTIVE: Mitochondrial aconitase (ACO2) is an essential enzyme that bridges the TCA cycle and lipid metabolism. However, its role in cancer development remains to be elucidated. The metabolic subtype of colorectal cancer (CRC) was recently established. We investigated ACO2's potential role in...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8042449/ https://www.ncbi.nlm.nih.gov/pubmed/33676027 http://dx.doi.org/10.1016/j.molmet.2021.101203 |