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Loss of mitochondrial aconitase promotes colorectal cancer progression via SCD1-mediated lipid remodeling

OBJECTIVE: Mitochondrial aconitase (ACO2) is an essential enzyme that bridges the TCA cycle and lipid metabolism. However, its role in cancer development remains to be elucidated. The metabolic subtype of colorectal cancer (CRC) was recently established. We investigated ACO2's potential role in...

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Detalles Bibliográficos
Autores principales:	You, Xin, Tian, Jingyu, Zhang, Hui, Guo, Yunhua, Yang, Jing, Zhu, Chaofeng, Song, Ming, Wang, Peng, Liu, Zexian, Cancilla, John, Lu, Wenhua, Glorieux, Christophe, Wen, Shijun, Du, Hongli, Huang, Peng, Hu, Yumin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8042449/ https://www.ncbi.nlm.nih.gov/pubmed/33676027 http://dx.doi.org/10.1016/j.molmet.2021.101203

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