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Chiral isothiourea-catalyzed kinetic resolution of 4-hydroxy[2.2]paracyclophane
We herein report a method for the kinetic resolution of racemic 4-hydroxy[2.2]paracyclophane by means of a chiral isothiourea-catalyzed acylation with isobutyric anhydride. This protocol allows for a reasonable synthetically useful s-factor of 20 and provides a novel entry to obtain this interesting...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Beilstein-Institut
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8042488/ https://www.ncbi.nlm.nih.gov/pubmed/33889220 http://dx.doi.org/10.3762/bjoc.17.68 |