Cargando…

Cannabidiol inhibits the skeletal muscle Nav1.4 by blocking its pore and by altering membrane elasticity

Cannabidiol (CBD) is the primary nonpsychotropic phytocannabinoid found in Cannabis sativa, which has been proposed to be therapeutic against many conditions, including muscle spasms. Among its putative targets are voltage-gated sodium channels (Navs), which have been implicated in many conditions....

Descripción completa

Detalles Bibliográficos
Autores principales:	Ghovanloo, Mohammad-Reza, Choudhury, Koushik, Bandaru, Tagore S., Fouda, Mohamed A., Rayani, Kaveh, Rusinova, Radda, Phaterpekar, Tejas, Nelkenbrecher, Karen, Watkins, Abeline R., Poburko, Damon, Thewalt, Jenifer, Andersen, Olaf S., Delemotte, Lucie, Goodchild, Samuel J., Ruben, Peter C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8042605/ https://www.ncbi.nlm.nih.gov/pubmed/33836525 http://dx.doi.org/10.1085/jgp.202012701

Ejemplares similares

Cannabidiol increases gramicidin current in human embryonic kidney cells: An observational study
por: Ghovanloo, Mohammad-Reza, et al.
Publicado: (2022)

An α–π transition in S6 shapes the conformational cycle of the bacterial sodium channel NavAb
por: Choudhury, Koushik, et al.
Publicado: (2022)

Effects of acidosis on neuronal voltage-gated sodium channels: Nav1.1 and Nav1.3
por: Ghovanloo, Mohammad-Reza, et al.
Publicado: (2018)

Inhibitory effects of cannabidiol on voltage-dependent sodium currents
por: Ghovanloo, Mohammad-Reza, et al.
Publicado: (2018)

Modulation of Pore Opening of Eukaryotic Sodium Channels by π-Helices in S6
por: Choudhury, Koushik, et al.
Publicado: (2023)

Non-psychotropic phytocannabinoid interactions with voltage-gated sodium channels: An update on cannabidiol and cannabigerol
por: Ghovanloo, Mohammad-Reza, et al.
Publicado: (2022)

Cannabidiol and Sodium Channel Pharmacology: General Overview, Mechanism, and Clinical Implications
por: Ghovanloo, Mohammad-Reza, et al.
Publicado: (2021)

Differential Inhibition of Human Nav1.2 Resurgent and Persistent Sodium Currents by Cannabidiol and GS967
por: Mason, Emily R., et al.
Publicado: (2020)

Cannabidiol interactions with voltage-gated sodium channels
por: Sait, Lily Goodyer, et al.
Publicado: (2020)

A general mechanism for drug promiscuity: Studies with amiodarone and other antiarrhythmics
por: Rusinova, Radda, et al.
Publicado: (2015)

An open state of a voltage-gated sodium channel involving a π-helix and conserved pore-facing asparagine
por: Choudhury, Koushik, et al.
Publicado: (2022)

Absolute Quantification of Nav1.5 Expression by Targeted Mass Spectrometry
por: Adams, Sarah L., et al.
Publicado: (2022)

Dynamic Regulation of the Mitochondrial Proton Gradient during Cytosolic Calcium Elevations
por: Poburko, Damon, et al.
Publicado: (2011)

Folding similarity of the outer pore region in prokaryotic and eukaryotic sodium channels revealed by docking of conotoxins GIIIA, PIIIA, and KIIIA in a NavAb-based model of Nav1.4
por: Korkosh, Viacheslav S., et al.
Publicado: (2014)

Phosphoinositides alter lipid bilayer properties
por: Rusinova, Radda, et al.
Publicado: (2013)

Calcium ions open a selectivity filter gate during activation of the MthK potassium channel
por: Posson, David J., et al.
Publicado: (2015)

Physiological and Pathophysiological Insights of Nav1.4 and Nav1.5 Comparison
por: Loussouarn, Gildas, et al.
Publicado: (2016)

Subtype-specific responses of hKv7.4 and hKv7.5 channels to polyunsaturated fatty acids reveal an unconventional modulatory site and mechanism
por: Frampton, Damon JA, et al.
Publicado: (2022)

A novel approach to modelling water transport and drug diffusion through the stratum corneum
por: Marquez-Lago, Tatiana T, et al.
Publicado: (2010)

Pharmacological determination of the fractional block of Nav channels required to impair neuronal excitability and ex vivo seizures
por: Thouta, Samrat, et al.
Publicado: (2022)

Left-Shifted Nav Channels in Injured Bilayer: Primary Targets for Neuroprotective Nav Antagonists?
por: Morris, Catherine E., et al.
Publicado: (2012)

Animal Toxins Can Alter the Function of Nav1.8 and Nav1.9
por: Gilchrist, John, et al.
Publicado: (2012)

Identification of Navβ1 Residues Involved in the Modulation of the Sodium Channel Nav1.4
por: Islas, Angel A., et al.
Publicado: (2013)

German Language Adaptation of the NAVS (NAVS-G) and of the NAT (NAT-G): Testing Grammar in Aphasia
por: Ditges, Ruth, et al.
Publicado: (2021)

OPA1 promotes pH flashes that spread between contiguous mitochondria without matrix protein exchange
por: Santo-Domingo, Jaime, et al.
Publicado: (2013)

Pulsed Electric Fields Can Create Pores in the Voltage Sensors of Voltage-Gated Ion Channels
por: Rems, Lea, et al.
Publicado: (2020)

Capsaicin as an amphipathic modulator of Na(V)1.5 mechanosensitivity
por: Cowan, Luke M., et al.
Publicado: (2022)

Microsoft Dynamics NAV development quick start guide: get up and running with Microsoft Dynamics NAV
por: Drogin, Alexander
Publicado: (2018)

Nav1.7 and Nav1.8: Diabetes-induced Changes in Primary Sensory Neurons in Rats
por: Lv, Jianlin, et al.
Publicado: (2016)

Implementing Microsoft Dynamics NAV 2009
por: Roys, David, et al.
Publicado: (2009)

Implementing Microsoft Dynamics NAV: explore the capabilities of Dynamics NAV 2016 and discover all you need to implement it
por: Chow, Alex
Publicado: (2016)

Heterologous functional expression of ascidian Nav1 channels and close relationship with the evolutionary ancestor of vertebrate Nav channels
por: Kawai, Takafumi, et al.
Publicado: (2021)

MicroRNA-9 induces defective trafficking of Nav1.1 and Nav1.2 by targeting Navβ2 protein coding region in rat with chronic brain hypoperfusion
por: Sun, Li-Hua, et al.
Publicado: (2015)

Interplay between VSD, pore, and membrane lipids in electromechanical coupling in HCN channels
por: Elbahnsi, Ahmad, et al.
Publicado: (2023)

Mastering Microsoft Dynamics NAV 2016: the compilation of best skillset to harness Microsoft Dynamics NAV for administrators, consultants, and developers
por: Sah, Rabindra
Publicado: (2017)

Building ERP solutions with Microsoft Dynamics NAV: create real-world enterprise solutions with NAV, Cloud and the Microsoft stack
por: Demiliani, Stefano
Publicado: (2017)

Thiazolidinedione insulin sensitizers alter lipid bilayer properties and voltage-dependent sodium channel function: implications for drug discovery
por: Rusinova, Radda, et al.
Publicado: (2011)

Electroacupuncture Reduces Carrageenan- and CFA-Induced Inflammatory Pain Accompanied by Changing the Expression of Nav1.7 and Nav1.8, rather than Nav1.9, in Mice Dorsal Root Ganglia
por: Huang, Chun-Ping, et al.
Publicado: (2013)

Gating Pore Currents in DIIS4 Mutations of NaV1.4 Associated with Periodic Paralysis: Saturation of Ion Flux and Implications for Disease Pathogenesis
por: Struyk, Arie F., et al.
Publicado: (2008)

Microsoft Dynamics NAV 2016 financial management
por: Bala, Anju, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_qps6a0a53mnfeh827k3s5eutuv