Petasin and isopetasin reduce CGRP release from trigeminal afferents indicating an inhibitory effect on TRPA1 and TRPV1 receptor channels

BACKGROUND: Butterbur root extract with its active ingredients petasin and isopetasin has been used in the prophylactic treatment of migraine for years, while its sites of action are not completely clear. Calcitonin gene-related peptide (CGRP) is known as a biomarker and promoting factor of migraine...

Descripción completa

Detalles Bibliográficos
Autores principales: Kleeberg-Hartmann, Johanna, Vogler, Birgit, Messlinger, Karl
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Milan 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8042690/
https://www.ncbi.nlm.nih.gov/pubmed/33849430
http://dx.doi.org/10.1186/s10194-021-01235-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8042690/
https://www.ncbi.nlm.nih.gov/pubmed/33849430
http://dx.doi.org/10.1186/s10194-021-01235-5

Ejemplares similares