Cargando…

Selective Permeabilization of Gram-Negative Bacterial Membranes Using Multivalent Peptide Constructs for Antibiotic Sensitization

[Image: see text] The drug-impermeable bacterial membrane in Gram-negative pathogens limits antibiotic access to intracellular drug targets. To expand our rapidly waning antibiotic arsenal, one approach is to improve the intracellular delivery of drugs with historically poor accumulation in Gram-neg...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chan, Leslie W., Hern, Kelsey E., Ngambenjawong, Chayanon, Lee, Katie, Kwon, Ester J., Hung, Deborah T., Bhatia, Sangeeta N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2021
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8043124/ https://www.ncbi.nlm.nih.gov/pubmed/33689277 http://dx.doi.org/10.1021/acsinfecdis.0c00805

Ejemplares similares

Conditional Antimicrobial Peptide Therapeutics
por: Ngambenjawong, Chayanon, et al.
Publicado: (2022)

Serum Stability and Affinity Optimization of an M2 Macrophage-Targeting Peptide (M2pep)
por: Ngambenjawong, Chayanon, et al.
Publicado: (2016)

Versatile Synthesis of Multivalent Porphyrin–Peptide Conjugates by Direct Porphyrin Construction on Resin
por: Wu, Yue, et al.
Publicado: (2022)

Membrane permeabilization of colistin toward pan-drug resistant Gram-negative isolates()
por: Mohamed, Yasmine Fathy, et al.
Publicado: (2016)

Resolution of Eczema with Multivalent Peptides
por: Eggink, Laura L., et al.
Publicado: (2022)

CRISPR-Cas-amplified urinary biomarkers for multiplexed and portable cancer diagnostics
por: Hao, Liangliang, et al.
Publicado: (2023)

Exploring monovalent and multivalent peptides for the inhibition of FBP21-tWW
por: Henning, Lisa Maria, et al.
Publicado: (2015)

Synergistic effect of clinically used antibiotics and peptide antibiotics against Gram-positive and Gram-negative bacteria
por: ZHOU, YULING, et al.
Publicado: (2013)

Impacts of Hydrophobic Mismatch on Antimicrobial Peptide Efficacy and Bilayer Permeabilization
por: Meier, Steven, et al.
Publicado: (2023)

In vitro Activity of Robenidine Analog NCL195 in Combination With Outer Membrane Permeabilizers Against Gram-Negative Bacterial Pathogens and Impact on Systemic Gram-Positive Bacterial Infection in Mice
por: Pi, Hongfei, et al.
Publicado: (2020)

Outer Membrane Permeabilization Is an Essential Step in the Killing of Gram-Negative Bacteria by the Lectin RegIIIβ
por: Miki, Tsuyoshi, et al.
Publicado: (2013)

Efficacy of Antibacterial Peptides Against Peptide-Resistant MRSA Is Restored by Permeabilization of Bacteria Membranes
por: Ravensdale, Joshua, et al.
Publicado: (2016)

Multivalent Antimicrobial Polymer Nanoparticles Target Mycobacteria and Gram-Negative Bacteria by Distinct Mechanisms
por: Richards, Sarah-Jane, et al.
Publicado: (2017)

Outer membrane permeabilization by the membrane attack complex sensitizes Gram-negative bacteria to antimicrobial proteins in serum and phagocytes
por: Heesterbeek, Dani A. C., et al.
Publicado: (2021)

Permeabilized microbes in biotechnology
por: Wackett, Lawrence P
Publicado: (2014)

Synthetic Multivalent Antifungal Peptides Effective against Fungi
por: Lakshminarayanan, Rajamani, et al.
Publicado: (2014)

Impact of multivalent charge presentation on peptide–nanoparticle aggregation
por: Schöne, Daniel, et al.
Publicado: (2015)

Multivalent Peptide–Nanoparticle Conjugates for Influenza‐Virus Inhibition
por: Lauster, Daniel, et al.
Publicado: (2017)

Thrombin-Derived Peptides Potentiate the Activity of Gram-Positive-Specific Antibiotics against Gram-Negative Bacteria
por: Wesseling, Charlotte M. J., et al.
Publicado: (2021)

The Efflux Inhibitor Phenylalanine-Arginine Beta-Naphthylamide (PAβN) Permeabilizes the Outer Membrane of Gram-Negative Bacteria
por: Lamers, Ryan P., et al.
Publicado: (2013)

Guanidinylated Polymyxins as Outer Membrane Permeabilizers Capable of Potentiating Rifampicin, Erythromycin, Ceftazidime and Aztreonam against Gram-Negative Bacteria
por: Ramirez, Danzel Marie, et al.
Publicado: (2022)

Menadione (vitamin K) enhances the antibiotic activity of drugs by cell membrane permeabilization mechanism
por: Andrade, Jacqueline C., et al.
Publicado: (2017)

Natural outer membrane permeabilizers boost antibiotic action against irradiated resistant bacteria
por: Farrag, Hala A., et al.
Publicado: (2019)

Synthesis of multivalent host and guest molecules for the construction of multithreaded diamide pseudorotaxanes
por: Löw, Nora L, et al.
Publicado: (2012)

Multivalent Antimicrobial Peptides as Therapeutics: Design Principles and Structural Diversities
por: Liu, S. P., et al.
Publicado: (2010)

Multivalent display of the antimicrobial peptides BP100 and BP143
por: Güell, Imma, et al.
Publicado: (2012)

Proofreading of Peptide—MHC Complexes through Dynamic Multivalent Interactions
por: Thomas, Christoph, et al.
Publicado: (2017)

Multivalent Peptide Ligands To Probe the Chromocenter Microenvironment in Living Cells
por: Guidotti, Nora, et al.
Publicado: (2022)

Antimicrobial Action of the Cyclic Peptide Bactenecin on Burkholderia pseudomallei Correlates with Efficient Membrane Permeabilization
por: Madhongsa, Kanjana, et al.
Publicado: (2013)

Antimicrobial Peptides: Insights into Membrane Permeabilization, Lipopolysaccharide Fragmentation and Application in Plant Disease Control
por: Datta, Aritreyee, et al.
Publicado: (2015)

Potentiating the Anti-Tuberculosis Efficacy of Peptide Nucleic Acids through Combinations with Permeabilizing Drugs
por: Cotta, Karishma Berta, et al.
Publicado: (2022)

An amphipathic peptide with antibiotic activity against multidrug-resistant Gram-negative bacteria
por: Elliott, Alysha G., et al.
Publicado: (2020)

A synthetic peptide sensitizes multi-drug resistant Pseudomonas aeruginosa to antibiotics for more than two hours and permeabilizes its envelope for twenty hours
por: Rázquin-Olazarán, Iosu, et al.
Publicado: (2020)

Pre-Clinical Assessment of Novel Multivalent MSP3 Malaria Vaccine Constructs
por: Bang, Gilles, et al.
Publicado: (2011)

Rational multivalency construction enables bactericidal effect amplification and dynamic biomaterial design
por: Chen, Xu, et al.
Publicado: (2023)

Solid-Phase Synthesis of Self-Assembling Multivalent π-Conjugated Peptides
por: Sanders, Allix M., et al.
Publicado: (2017)

Molecular Dynamics Simulations of a Catalytic Multivalent Peptide–Nanoparticle Complex
por: Dutta, Sutapa, et al.
Publicado: (2021)

A 3D Peptide/[60]Fullerene Hybrid for Multivalent Recognition
por: Gallego, Iván, et al.
Publicado: (2022)

Mechanisms of light‐induced liposome permeabilization
por: Miranda, Dyego, et al.
Publicado: (2016)

Permeabilizing Cell Membranes with Electric Fields
por: Aguilar, Alondra A., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_g5be6j2tnfush6mnc9utcmovfe