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Calculation of therapeutic antibody viscosity with coarse-grained models, hydrodynamic calculations and machine learning-based parameters

High viscosity presents a challenge for manufacturing and drug delivery of therapeutic antibodies. The viscosity is determined by protein–protein interactions among many antibodies. Molecular simulation is a promising method to study protein–protein interactions; however, all-atom models do not allo...

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Detalles Bibliográficos
Autores principales: Lai, Pin-Kuang, Swan, James W., Trout, Bernhardt L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8043186/
https://www.ncbi.nlm.nih.gov/pubmed/33834944
http://dx.doi.org/10.1080/19420862.2021.1907882