Structural determinants for subnanomolar inhibition of the secreted aspartic protease Sapp1p from Candida parapsilosis

Pathogenic Candida albicans yeasts frequently cause infections in hospitals. Antifungal drugs lose effectiveness due to other Candida species and resistance. New medications are thus required. Secreted aspartic protease of C. parapsilosis (Sapp1p) is a promising target. We have thus solved the cryst...

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Detalles Bibliográficos
Autores principales: Dostál, Jiří, Brynda, Jiří, Vaňková, Lucie, Zia, Syeda Rehana, Pichová, Iva, Heidingsfeld, Olga, Lepšík, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8043539/
https://www.ncbi.nlm.nih.gov/pubmed/33843395
http://dx.doi.org/10.1080/14756366.2021.1906664

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8043539/
https://www.ncbi.nlm.nih.gov/pubmed/33843395
http://dx.doi.org/10.1080/14756366.2021.1906664

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