Mapping the functional landscape of the receptor binding domain of T7 bacteriophage by deep mutational scanning

The interaction between a bacteriophage and its host is mediated by the phage's receptor binding protein (RBP). Despite its fundamental role in governing phage activity and host range, molecular rules of RBP function remain a mystery. Here, we systematically dissect the functional role of every...

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Detalles Bibliográficos
Autores principales: Huss, Phil, Meger, Anthony, Leander, Megan, Nishikawa, Kyle, Raman, Srivatsan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8043750/
https://www.ncbi.nlm.nih.gov/pubmed/33687327
http://dx.doi.org/10.7554/eLife.63775

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8043750/
https://www.ncbi.nlm.nih.gov/pubmed/33687327
http://dx.doi.org/10.7554/eLife.63775

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