Cryo-EM structures of tau filaments from Alzheimer’s disease with PET ligand APN-1607

Tau and Aβ assemblies of Alzheimer’s disease (AD) can be visualized in living subjects using positron emission tomography (PET). Tau assemblies comprise paired helical and straight filaments (PHFs and SFs). APN-1607 (PM-PBB3) is a recently described PET ligand for AD and other tau proteinopathies. S...

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Detalles Bibliográficos
Autores principales: Shi, Yang, Murzin, Alexey G., Falcon, Benjamin, Epstein, Alexander, Machin, Jonathan, Tempest, Paul, Newell, Kathy L., Vidal, Ruben, Garringer, Holly J., Sahara, Naruhiko, Higuchi, Makoto, Ghetti, Bernardino, Jang, Ming-Kuei, Scheres, Sjors H. W., Goedert, Michel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8043864/
https://www.ncbi.nlm.nih.gov/pubmed/33723967
http://dx.doi.org/10.1007/s00401-021-02294-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8043864/
https://www.ncbi.nlm.nih.gov/pubmed/33723967
http://dx.doi.org/10.1007/s00401-021-02294-3

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