SKI activates the Hippo pathway via LIMD1 to inhibit cardiac fibroblast activation

We have previously shown that overexpression of SKI, an endogenous TGF-β(1) repressor, deactivates the pro-fibrotic myofibroblast phenotype in the heart. We now show that SKI also functions independently of SMAD/TGF-β signaling, by activating the Hippo tumor-suppressor pathway and inhibiting the Tra...

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Detalles Bibliográficos
Autores principales: Landry, Natalie M., Rattan, Sunil G., Filomeno, Krista L., Meier, Thomas W., Meier, Simon C., Foran, Sarah J., Meier, Claire F., Koleini, Navid, Fandrich, Robert R., Kardami, Elissavet, Duhamel, Todd A., Dixon, Ian M. C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Original Contribution
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8043893/
https://www.ncbi.nlm.nih.gov/pubmed/33847835
http://dx.doi.org/10.1007/s00395-021-00865-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8043893/
https://www.ncbi.nlm.nih.gov/pubmed/33847835
http://dx.doi.org/10.1007/s00395-021-00865-9

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