The mechanistic link between selective vulnerability of the locus coeruleus and neurodegeneration in Alzheimer’s disease

Alzheimer’s disease (AD) is neuropathologically characterized by the intracellular accumulation of hyperphosphorylated tau and the extracellular deposition of amyloid-β plaques, which affect certain brain regions in a progressive manner. The locus coeruleus (LC), a small nucleus in the pons of the b...

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Detalles Bibliográficos
Autores principales: Matchett, Billie J., Grinberg, Lea T., Theofilas, Panos, Murray, Melissa E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8043919/
https://www.ncbi.nlm.nih.gov/pubmed/33427939
http://dx.doi.org/10.1007/s00401-020-02248-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8043919/
https://www.ncbi.nlm.nih.gov/pubmed/33427939
http://dx.doi.org/10.1007/s00401-020-02248-1

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