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The mechanistic link between selective vulnerability of the locus coeruleus and neurodegeneration in Alzheimer’s disease
Alzheimer’s disease (AD) is neuropathologically characterized by the intracellular accumulation of hyperphosphorylated tau and the extracellular deposition of amyloid-β plaques, which affect certain brain regions in a progressive manner. The locus coeruleus (LC), a small nucleus in the pons of the b...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer Berlin Heidelberg
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8043919/ https://www.ncbi.nlm.nih.gov/pubmed/33427939 http://dx.doi.org/10.1007/s00401-020-02248-1 |