Computationally-guided exchange of substrate selectivity motifs in a modular polyketide synthase acyltransferase

Polyketides, one of the largest classes of natural products, are often clinically relevant. The ability to engineer polyketide biosynthesis to produce analogs is critically important. Acyltransferases (ATs) of modular polyketide synthases (PKSs) catalyze the installation of malonyl-CoA extenders int...

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Detalles Bibliográficos
Autores principales: Kalkreuter, Edward, Bingham, Kyle S., Keeler, Aaron M., Lowell, Andrew N., Schmidt, Jennifer J., Sherman, David H., Williams, Gavin J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8044089/
https://www.ncbi.nlm.nih.gov/pubmed/33850151
http://dx.doi.org/10.1038/s41467-021-22497-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8044089/
https://www.ncbi.nlm.nih.gov/pubmed/33850151
http://dx.doi.org/10.1038/s41467-021-22497-2

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