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Low biological fluctuation of mitochondrial CpG and non-CpG methylation at the single-molecule level
Mammalian cytosine DNA methylation (5mC) is associated with the integrity of the genome and the transcriptional status of nuclear DNA. Due to technical limitations, it has been less clear if mitochondrial DNA (mtDNA) is methylated and whether 5mC has a regulatory role in this context. Here, we used...
Autores principales: | Goldsmith, Chloe, Rodríguez-Aguilera, Jesús Rafael, El-Rifai, Ines, Jarretier-Yuste, Adrien, Hervieu, Valérie, Raineteau, Olivier, Saintigny, Pierre, Chagoya de Sánchez, Victoria, Dante, Robert, Ichim, Gabriel, Hernandez-Vargas, Hector |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8044111/ https://www.ncbi.nlm.nih.gov/pubmed/33850190 http://dx.doi.org/10.1038/s41598-021-87457-8 |
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