Methylglyoxal induces p53 activation and inhibits mTORC1 in human umbilical vein endothelial cells

Methylglyoxal (MGO), a precursor of advanced glycation end products (AGEs), is regarded as a pivotal mediator of vascular damage in patients with diabetes. We have previously reported that MGO induces transcriptional changes compatible with p53 activation in cultured human endothelial cells. To furt...

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Detalles Bibliográficos
Autores principales: Zhang, Xinmiao, Rodriguez-Niño, Angelica, Pastene, Diego O., Pallavi, Prama, van den Born, Jacob, Bakker, Stephan J. L., Krämer, Bernhard K., Yard, Benito A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8044125/
https://www.ncbi.nlm.nih.gov/pubmed/33850227
http://dx.doi.org/10.1038/s41598-021-87561-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8044125/
https://www.ncbi.nlm.nih.gov/pubmed/33850227
http://dx.doi.org/10.1038/s41598-021-87561-9

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