Cargando…

Characterization of combined linagliptin and Y2R agonist treatment in diet-induced obese mice

Dipeptidyl peptidase IV (DPP-IV) inhibitors improve glycemic control by prolonging the action of glucagon-like peptide-1 (GLP-1). In contrast to GLP-1 analogues, DPP-IV inhibitors are weight-neutral. DPP-IV cleavage of PYY and NPY gives rise to PYY(3-36) and NPY(3-36) which exert potent anorectic ac...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hansen, Henrik H., Grønlund, Rikke V., Baader-Pagler, Tamara, Haebel, Peter, Tammen, Harald, Larsen, Leif Kongskov, Jelsing, Jacob, Vrang, Niels, Klein, Thomas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8044192/ https://www.ncbi.nlm.nih.gov/pubmed/33850212 http://dx.doi.org/10.1038/s41598-021-87539-7

Ejemplares similares

Expression of the Fatty Acid Receptor GPR120 in the Gut of Diet-Induced-Obese Rats and Its Role in GLP-1 Secretion
por: Paulsen, Sarah Juel, et al.
Publicado: (2014)

A Hamster Model of Diet-Induced Obesity for Preclinical Evaluation of Anti-Obesity, Anti-Diabetic and Lipid Modulating Agents
por: Dalbøge, Louise S., et al.
Publicado: (2015)

BI 456906: Discovery and preclinical pharmacology of a novel GCGR/GLP-1R dual agonist with robust anti-obesity efficacy
por: Zimmermann, Tina, et al.
Publicado: (2022)

Metabolic and gut microbiome changes following GLP-1 or dual GLP-1/GLP-2 receptor agonist treatment in diet-induced obese mice
por: Madsen, Mette Simone Aae, et al.
Publicado: (2019)

Metabolic and hepatic effects of liraglutide, obeticholic acid and elafibranor in diet-induced obese mouse models of biopsy-confirmed nonalcoholic steatohepatitis
por: Tølbøl, Kirstine S, et al.
Publicado: (2018)

Alterations in hypothalamic gene expression following Roux-en-Y gastric bypass
por: Barkholt, Pernille, et al.
Publicado: (2016)

The IL-1β Receptor Antagonist SER140 Postpones the Onset of Diabetes in Female Nonobese Diabetic Mice
por: Cucak, Helena, et al.
Publicado: (2016)

The GLP-1 Receptor Agonist Liraglutide Improves Memory Function and Increases Hippocampal CA1 Neuronal Numbers in a Senescence-Accelerated Mouse Model of Alzheimer’s Disease
por: Hansen, Henrik H., et al.
Publicado: (2015)

Linagliptin treatment is associated with altered cobalamin (VitB12) homeostasis in mice and humans
por: Tammen, Harald, et al.
Publicado: (2023)

Long-Term Treatment with Liraglutide, a Glucagon-Like Peptide-1 (GLP-1) Receptor Agonist, Has No Effect on β-Amyloid Plaque Load in Two Transgenic APP/PS1 Mouse Models of Alzheimer’s Disease
por: Hansen, Henrik H., et al.
Publicado: (2016)

Lipidated PrRP31 metabolites are long acting dual GPR10 and NPFF2 receptor agonists with potent body weight lowering effect
por: Alexopoulou, Flora, et al.
Publicado: (2022)

Linagliptin Improves Insulin Sensitivity and Hepatic Steatosis in Diet-Induced Obesity
por: Kern, Matthias, et al.
Publicado: (2012)

Validity of biopsy-based drug effects in a diet-induced obese mouse model of biopsy-confirmed NASH
por: Baandrup Kristiansen, Maria Nicoline, et al.
Publicado: (2019)

3D quantification of changes in pancreatic islets in mouse models of diabetes type I and II
por: Roostalu, Urmas, et al.
Publicado: (2020)

Multi-omics characterization of a diet-induced obese model of non-alcoholic steatohepatitis
por: Ægidius, Helene M., et al.
Publicado: (2020)

INT-767 improves histopathological features in a diet-induced ob/ob mouse model of biopsy-confirmed non-alcoholic steatohepatitis
por: Roth, Jonathan D, et al.
Publicado: (2018)

Hepatoprotective effects of semaglutide, lanifibranor and dietary intervention in the GAN diet‐induced obese and biopsy‐confirmed mouse model of NASH
por: Møllerhøj, Mathias B., et al.
Publicado: (2022)

Hypertrophy Dependent Doubling of L-Cells in Roux-en-Y Gastric Bypass Operated Rats
por: Hansen, Carl Frederik, et al.
Publicado: (2013)

Combined obeticholic acid and elafibranor treatment promotes additive liver histological improvements in a diet-induced ob/ob mouse model of biopsy-confirmed NASH
por: Roth, Jonathan D., et al.
Publicado: (2019)

Global transcriptome analysis of rat hypothalamic arcuate nucleus demonstrates reversal of hypothalamic gliosis following surgically and diet induced weight loss
por: Barkholt, Pernille, et al.
Publicado: (2019)

Human translatability of the GAN diet-induced obese mouse model of non-alcoholic steatohepatitis
por: Hansen, Henrik H., et al.
Publicado: (2020)

Whole-brain activation signatures of weight-lowering drugs
por: Hansen, Henrik H., et al.
Publicado: (2021)

Effects of a long-acting secretin peptide analog alone and in combination with a GLP-1R agonist in a diet-induced obesity mouse model
por: Loeffler, Mona, et al.
Publicado: (2023)

Towards a standard diet-induced and biopsy-confirmed mouse model of non-alcoholic steatohepatitis: Impact of dietary fat source
por: Boland, Michelle L, et al.
Publicado: (2019)

The endogenous preproglucagon system is not essential for gut growth homeostasis in mice
por: Wismann, Pernille, et al.
Publicado: (2017)

Disease Progression and Pharmacological Intervention in a Nutrient-Deficient Rat Model of Nonalcoholic Steatohepatitis
por: Tølbøl, Kirstine S., et al.
Publicado: (2018)

Characterisation of Age-Dependent Beta Cell Dynamics in the Male db/db Mice
por: Dalbøge, Louise S., et al.
Publicado: (2013)

The clinical application of linagliptin in Asians
por: Cao, Chu-qing, et al.
Publicado: (2015)

Linagliptin: from bench to bedside
por: Doupis, John
Publicado: (2014)

Dipeptidyl peptidase-4 inhibition with linagliptin prevents western diet-induced vascular abnormalities in female mice
por: Manrique, Camila, et al.
Publicado: (2016)

Quantitative whole-brain 3D imaging of tyrosine hydroxylase-labeled neuron architecture in the mouse MPTP model of Parkinson's disease
por: Roostalu, Urmas, et al.
Publicado: (2019)

Effect of captopril on post-infarction remodelling visualized by light sheet microscopy and echocardiography
por: Roostalu, Urmas, et al.
Publicado: (2021)

Incorrect description of mode of excretion of linagliptin
por: Woerle, Hans-Juergen, et al.
Publicado: (2010)

Acute Kidney Injury Associated with Linagliptin
por: Nandikanti, Deepak K., et al.
Publicado: (2016)

Linagliptin-Associated Alopecia and Bullous Pemphigoid
por: Someili, Ali, et al.
Publicado: (2019)

Analytical Enantio-Separation of Linagliptin in Linagliptin and Metformin HCl Dosage Forms by Applying Two-Level Factorial Design
por: Jadhav, Sushant B., et al.
Publicado: (2016)

Application of the Physical Disector Principle for Quantification of Dopaminergic Neuronal Loss in a Rat 6-Hydroxydopamine Nigral Lesion Model of Parkinson's Disease
por: Fabricius, Katrine, et al.
Publicado: (2017)

An Optimized Mouse Brain Atlas for Automated Mapping and Quantification of Neuronal Activity Using iDISCO+ and Light Sheet Fluorescence Microscopy
por: Perens, Johanna, et al.
Publicado: (2020)

The DPP-4 Inhibitor Linagliptin Counteracts Stroke in the Normal and Diabetic Mouse Brain: A Comparison With Glimepiride
por: Darsalia, Vladimer, et al.
Publicado: (2013)

Linagliptin improves endothelial function in patients with type 2 diabetes: A randomized study of linagliptin effectiveness on endothelial function
por: Shigiyama, Fumika, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_njsvsmenejp3j5nle3acfigrjr