Mediator subunit Med15 dictates the conserved “fuzzy” binding mechanism of yeast transcription activators Gal4 and Gcn4

The acidic activation domain (AD) of yeast transcription factor Gal4 plays a dual role in transcription repression and activation through binding to Gal80 repressor and Mediator subunit Med15. The activation function of Gal4 arises from two hydrophobic regions within the 40-residue AD. We show by NM...

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Detalles Bibliográficos
Autores principales: Tuttle, Lisa M., Pacheco, Derek, Warfield, Linda, Wilburn, Damien B., Hahn, Steven, Klevit, Rachel E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8044209/
https://www.ncbi.nlm.nih.gov/pubmed/33850123
http://dx.doi.org/10.1038/s41467-021-22441-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8044209/
https://www.ncbi.nlm.nih.gov/pubmed/33850123
http://dx.doi.org/10.1038/s41467-021-22441-4

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