IL‐3 is essential for ICOS‐L stabilization on mast cells, and sustains the IL‐33‐induced RORγt(+) T(reg) generation via enhanced IL‐6 induction

IL‐33 is a member of the IL‐1 family. By binding to its receptor ST2 (IL‐33R) on mast cells, IL‐33 induces the MyD88‐dependent activation of the TAK1‐IKK2 signalling module resulting in activation of the MAP kinases p38, JNK1/2 and ERK1/2, and of NFκB. Depending on the kinases activated in these pat...

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Detalles Bibliográficos
Autores principales: Drube, Sebastian, Müller, Sylvia, Weber, Franziska, Wegner, Philine, Böttcher‐Loschinski, Romy, Gaestel, Matthias, Hutloff, Andreas, Kamradt, Thomas, Andreas, Nico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8044339/
https://www.ncbi.nlm.nih.gov/pubmed/33427298
http://dx.doi.org/10.1111/imm.13305

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8044339/
https://www.ncbi.nlm.nih.gov/pubmed/33427298
http://dx.doi.org/10.1111/imm.13305

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