Microglial Activation Mediates Noradrenergic Locus Coeruleus Neurodegeneration via Complement Receptor 3 in a Rotenone-Induced Parkinson’s Disease Mouse Model

BACKGROUND: Chronic exposure to the insecticide rotenone can damage dopaminergic neurons and lead to an increased risk of Parkinson’s disease (PD). Whereas it is not clear whether rotenone induces neurodegeneration of noradrenergic locus coeruleus (LC/NE) neurons. Chronic neuroinflammation mediated...

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Detalles Bibliográficos
Autores principales: Jing, Lu, Hou, Liyan, Zhang, Dongdong, Li, Sheng, Ruan, Zhengzheng, Zhang, Xiaomeng, Hong, Jau-Shyong, Wang, Qingshan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8044341/
https://www.ncbi.nlm.nih.gov/pubmed/33859489
http://dx.doi.org/10.2147/JIR.S299927

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8044341/
https://www.ncbi.nlm.nih.gov/pubmed/33859489
http://dx.doi.org/10.2147/JIR.S299927

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