AAV-S: A versatile capsid variant for transduction of mouse and primate inner ear

Gene therapy strategies using adeno-associated virus (AAV) vectors to treat hereditary deafnesses have shown remarkable efficacy in some mouse models of hearing loss. Even so, there are few AAV capsids that transduce both inner and outer hair cells—the cells that express most deafness genes—and fewe...

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Detalles Bibliográficos
Autores principales: Ivanchenko, Maryna V., Hanlon, Killian S., Hathaway, Daniel M., Klein, Alex J., Peters, Cole W., Li, Yaqiao, Tamvakologos, Panos I., Nammour, Josette, Maguire, Casey A., Corey, David P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8044388/
https://www.ncbi.nlm.nih.gov/pubmed/33869656
http://dx.doi.org/10.1016/j.omtm.2021.03.019

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8044388/
https://www.ncbi.nlm.nih.gov/pubmed/33869656
http://dx.doi.org/10.1016/j.omtm.2021.03.019

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