Suppression of elevated Cdc42 activity promotes the regenerative potential of aged intestinal stem cells

Homeostasis in the intestinal epithelium is maintained by Lgr5-positive intestinal stem cells (ISCs) located at the base of the crypt. The function of ISCs is reduced upon aging which leads to a decline of regeneration of the intestinal epithelium. We report that aged intestinal crypts present with...

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Detalles Bibliográficos
Autores principales: Nalapareddy, Kodandaramireddy, Hassan, Aishlin, Sampson, Leesa L., Zheng, Yi, Geiger, Hartmut
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8044426/
https://www.ncbi.nlm.nih.gov/pubmed/33870147
http://dx.doi.org/10.1016/j.isci.2021.102362

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8044426/
https://www.ncbi.nlm.nih.gov/pubmed/33870147
http://dx.doi.org/10.1016/j.isci.2021.102362

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