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Suppression of elevated Cdc42 activity promotes the regenerative potential of aged intestinal stem cells
Homeostasis in the intestinal epithelium is maintained by Lgr5-positive intestinal stem cells (ISCs) located at the base of the crypt. The function of ISCs is reduced upon aging which leads to a decline of regeneration of the intestinal epithelium. We report that aged intestinal crypts present with...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8044426/ https://www.ncbi.nlm.nih.gov/pubmed/33870147 http://dx.doi.org/10.1016/j.isci.2021.102362 |