Genetic or pharmacological reduction of cholangiocyte senescence improves inflammation and fibrosis in the Mdr2(-/-) mouse

BACKGROUND & AIMS: Cholangiocyte senescence is important in the pathogenesis of primary sclerosing cholangitis (PSC). We found that CDKN2A (p16), a cyclin-dependent kinase inhibitor and mediator of senescence, was increased in cholangiocytes of patients with PSC and from a PSC mouse model (multi...

Descripción completa

Detalles Bibliográficos
Autores principales: Alsuraih, Mohammed, O’Hara, Steven P., Woodrum, Julie E., Pirius, Nicholas E., LaRusso, Nicholas F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8044431/
https://www.ncbi.nlm.nih.gov/pubmed/33870156
http://dx.doi.org/10.1016/j.jhepr.2021.100250

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8044431/
https://www.ncbi.nlm.nih.gov/pubmed/33870156
http://dx.doi.org/10.1016/j.jhepr.2021.100250

Ejemplares similares