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Genetic or pharmacological reduction of cholangiocyte senescence improves inflammation and fibrosis in the Mdr2(-/-) mouse

BACKGROUND & AIMS: Cholangiocyte senescence is important in the pathogenesis of primary sclerosing cholangitis (PSC). We found that CDKN2A (p16), a cyclin-dependent kinase inhibitor and mediator of senescence, was increased in cholangiocytes of patients with PSC and from a PSC mouse model (multi...

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Detalles Bibliográficos
Autores principales:	Alsuraih, Mohammed, O’Hara, Steven P., Woodrum, Julie E., Pirius, Nicholas E., LaRusso, Nicholas F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8044431/ https://www.ncbi.nlm.nih.gov/pubmed/33870156 http://dx.doi.org/10.1016/j.jhepr.2021.100250

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