A Nanomule Peptide Carrier Delivers siRNA Across the Intact Blood-Brain Barrier to Attenuate Ischemic Stroke

The blood-brain barrier (BBB) hinders the distribution of therapeutics intended for treatment of neuroinflammation (NI) of the central nervous system. A twelve-amino acid peptide that transcytoses the BBB, termed MTfp, was chemically conjugated to siRNA to create a novel peptide-oligonucleotide conj...

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Detalles Bibliográficos
Autores principales: Eyford, Brett A., Singh, Chaahat S. B., Abraham, Thomas, Munro, Lonna, Choi, Kyung Bok, Hill, Tracy, Hildebrandt, Rhonda, Welch, Ian, Vitalis, Timothy Z., Gabathuler, Reinhard, Gordon, Jacob A., Adomat, Hans, Guns, Emma S.T., Lu, Chieh-Ju, Pfeifer, Cheryl G., Tian, Mei Mei, Jefferies, Wilfred A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8044710/
https://www.ncbi.nlm.nih.gov/pubmed/33869275
http://dx.doi.org/10.3389/fmolb.2021.611367

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8044710/
https://www.ncbi.nlm.nih.gov/pubmed/33869275
http://dx.doi.org/10.3389/fmolb.2021.611367

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