Sirt6 Regulates the Development of Medullary Thymic Epithelial Cells and Contributes to the Establishment of Central Immune Tolerance

Although some advances have been made in understanding the molecular regulation of mTEC development, the role of epigenetic regulators in the development and maturation of mTEC is poorly understood. Here, using the TEC-specific Sirt6 knockout mice, we found the deacetylase Sirtuin 6 (Sirt6) is essen...

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Detalles Bibliográficos
Autores principales: Zhang, Qian, Liang, Zhanfeng, Zhang, Jiayu, Lei, Tong, Dong, Xue, Su, Huiting, Chen, Yifang, Zhang, Zhaoqi, Tan, Liang, Zhao, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8044826/
https://www.ncbi.nlm.nih.gov/pubmed/33869219
http://dx.doi.org/10.3389/fcell.2021.655552

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8044826/
https://www.ncbi.nlm.nih.gov/pubmed/33869219
http://dx.doi.org/10.3389/fcell.2021.655552

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