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Mendelian Randomization With Refined Instrumental Variables From Genetic Score Improves Accuracy and Reduces Bias
Mendelian randomization (MR) can estimate the causal effect for a risk factor on a complex disease using genetic variants as instrument variables (IVs). A variety of generalized MR methods have been proposed to integrate results arising from multiple IVs in order to increase power. One of the method...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8044958/ https://www.ncbi.nlm.nih.gov/pubmed/33868364 http://dx.doi.org/10.3389/fgene.2021.618829 |