CLK1/SRSF5 pathway induces aberrant exon skipping of METTL14 and Cyclin L2 and promotes growth and metastasis of pancreatic cancer

BACKGROUND: Both aberrant alternative splicing and m6A methylation play complicated roles in the development of pancreatic cancer (PC), while the relationship between these two RNA modifications remains unclear. METHODS: RNA sequencing (RNA-seq) was performed using 15 pairs of pancreatic ductal aden...

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Detalles Bibliográficos
Autores principales: Chen, Shi, Yang, Can, Wang, Zu-Wei, Hu, Jian-Fei, Pan, Jing-Jing, Liao, Cheng-Yu, Zhang, Jia-Qiang, Chen, Jiang-Zhi, Huang, Yi, Huang, Long, Zhan, Qian, Tian, Yi-Feng, Shen, Bai-Yong, Wang, Yao-Dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8045197/
https://www.ncbi.nlm.nih.gov/pubmed/33849617
http://dx.doi.org/10.1186/s13045-021-01072-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8045197/
https://www.ncbi.nlm.nih.gov/pubmed/33849617
http://dx.doi.org/10.1186/s13045-021-01072-8

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