COVID-19 as a mediator of interferon deficiency and hyperinflammation: Rationale for the use of JAK1/2 inhibitors in combination with interferon

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) elicits an interferon (IFN) deficiency state, which aggravates the type I interferon deficiency and slow IFN responses, which associate with e.g. aging and obesity. Additionally, SARS-CoV-2 may also elicit a cytokine storm, which accounts...

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Detalles Bibliográficos
Autores principales: Hasselbalch, H.C., Skov, V., Kjær, L., Ellervik, C., Poulsen, A., Poulsen, T.D., Nielsen, C.H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8045432/
https://www.ncbi.nlm.nih.gov/pubmed/33992887
http://dx.doi.org/10.1016/j.cytogfr.2021.03.006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8045432/
https://www.ncbi.nlm.nih.gov/pubmed/33992887
http://dx.doi.org/10.1016/j.cytogfr.2021.03.006

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