Chemoprotective Antimalarial Activity of P218 against Plasmodium falciparum: A Randomized, Placebo-Controlled Volunteer Infection Study

P218 is a highly selective dihydrofolate reductase inhibitor with potent in vitro activity against pyrimethamine-resistant Plasmodium falciparum. This single-center, randomized, double-blind, placebo-controlled phase Ib study evaluated P218 safety, pharmacokinetics, and chemoprotective efficacy in a...

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Detalles Bibliográficos
Autores principales: Chughlay, Mohamed Farouk, El Gaaloul, Myriam, Donini, Cristina, Campo, Brice, Berghmans, Pieter-Jan, Lucardie, Alexander, Marx, Michael W., Cherkaoui-Rbati, Mohammed H., Langdon, Grant, Angulo-Barturen, Iñigo, Viera, Sara, Rosanas-Urgell, Anna, Van Geertruyden, Jean-Pierre, Chalon, Stephan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society of Tropical Medicine and Hygiene 2021
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8045640/
https://www.ncbi.nlm.nih.gov/pubmed/33556040
http://dx.doi.org/10.4269/ajtmh.20-1165

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8045640/
https://www.ncbi.nlm.nih.gov/pubmed/33556040
http://dx.doi.org/10.4269/ajtmh.20-1165

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