A novel p53 regulator, C16ORF72/TAPR1, buffers against telomerase inhibition

Telomere erosion in cells with insufficient levels of the telomerase reverse transcriptase (TERT), contributes to age‐associated tissue dysfunction and senescence, and p53 plays a crucial role in this response. We undertook a genome‐wide CRISPR screen to identify gene deletions that sensitized p53‐p...

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Detalles Bibliográficos
Autores principales: Benslimane, Yahya, Sánchez‐Osuna, María, Coulombe‐Huntington, Jasmin, Bertomeu, Thierry, Henry, Danielle, Huard, Caroline, Bonneil, Éric, Thibault, Pierre, Tyers, Mike, Harrington, Lea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8045932/
https://www.ncbi.nlm.nih.gov/pubmed/33660365
http://dx.doi.org/10.1111/acel.13331

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8045932/
https://www.ncbi.nlm.nih.gov/pubmed/33660365
http://dx.doi.org/10.1111/acel.13331

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