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Functional genomic analyses highlight a shift in Gpr17‐regulated cellular processes in oligodendrocyte progenitor cells and underlying myelin dysregulation in the aged mouse cerebrum

Brain ageing is characterised by a decline in neuronal function and associated cognitive deficits. There is increasing evidence that myelin disruption is an important factor that contributes to the age‐related loss of brain plasticity and repair responses. In the brain, myelin is produced by oligode...

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Detalles Bibliográficos
Autores principales: Rivera, Andrea D., Pieropan, Francesca, Chacon‐De‐La‐Rocha, Irene, Lecca, Davide, Abbracchio, Maria P., Azim, Kasum, Butt, Arthur M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8045941/
https://www.ncbi.nlm.nih.gov/pubmed/33675110
http://dx.doi.org/10.1111/acel.13335