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Evaluation of the antiproliferative effects of the HASPIN inhibitor CHR-6494 in breast cancer cell lines
HASPIN is a serine/threonine kinase that regulates mitosis by phosphorylating histone H3 at threonine 3. The expression levels of HASPIN in various cancers are associated with tumor malignancy and poor survival, suggesting that HASPIN inhibition may suppress cancer growth. As HASPIN mRNA levels are...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8046223/ https://www.ncbi.nlm.nih.gov/pubmed/33852630 http://dx.doi.org/10.1371/journal.pone.0249912 |