Single-Cell and Population Transcriptomics Reveal Pan-epithelial Remodeling in Type 2-High Asthma

The type 2 cytokine-high asthma endotype (T2H) is characterized by IL-13-driven mucus obstruction of the airways. To further investigate this incompletely understood pathobiology, we characterize IL-13 effects on human airway epithelial cell cultures using single-cell RNA sequencing, finding that IL...

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Detalles Bibliográficos
Autores principales: Jackson, Nathan D., Everman, Jamie L., Chioccioli, Maurizio, Feriani, Luigi, Goldfarbmuren, Katherine C., Sajuthi, Satria P., Rios, Cydney L., Powell, Roger, Armstrong, Michael, Gomez, Joe, Michel, Cole, Eng, Celeste, Oh, Sam S., Rodriguez-Santana, Jose, Cicuta, Pietro, Reisdorph, Nichole, Burchard, Esteban G., Seibold, Max A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8046336/
https://www.ncbi.nlm.nih.gov/pubmed/32640237
http://dx.doi.org/10.1016/j.celrep.2020.107872

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8046336/
https://www.ncbi.nlm.nih.gov/pubmed/32640237
http://dx.doi.org/10.1016/j.celrep.2020.107872

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