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Novel Variance-Component TWAS method for studying complex human diseases with applications to Alzheimer’s dementia
Transcriptome-wide association studies (TWAS) have been widely used to integrate transcriptomic and genetic data to study complex human diseases. Within a test dataset lacking transcriptomic data, traditional two-stage TWAS methods first impute gene expression by creating a weighted sum that aggrega...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8046351/ https://www.ncbi.nlm.nih.gov/pubmed/33798195 http://dx.doi.org/10.1371/journal.pgen.1009482 |