Replicated chromatin curtails 53BP1 recruitment in BRCA1-proficient and BRCA1-deficient cells

DNA double-strand breaks can be repaired by non-homologous end-joining or homologous recombination. Which pathway is used depends on the balance between the tumor suppressors 53BP1 and BRCA1 and on the availability of an undamaged template DNA for homology-directed repair. How cells switch from a 53...

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Detalles Bibliográficos
Autores principales: Michelena, Jone, Pellegrino, Stefania, Spegg, Vincent, Altmeyer, Matthias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Life Science Alliance LLC 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8046418/
https://www.ncbi.nlm.nih.gov/pubmed/33811064
http://dx.doi.org/10.26508/lsa.202101023

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8046418/
https://www.ncbi.nlm.nih.gov/pubmed/33811064
http://dx.doi.org/10.26508/lsa.202101023

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