The ubiquitin ligase NEDD4-2/NEDD4L regulates both sodium homeostasis and fibrotic signaling to prevent end-stage renal disease

Kidney disease progression can be affected by Na(+) abundance. A key regulator of Na(+) homeostasis is the ubiquitin ligase NEDD4-2 and its deficiency leads to increased Na(+) transport activity and salt-sensitive progressive kidney damage. However, the mechanisms responsible for high Na(+) induced...

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Detalles Bibliográficos
Autores principales: Manning, Jantina A., Shah, Sonia S., Nikolic, Andrej, Henshall, Tanya L., Khew-Goodall, Yeesim, Kumar, Sharad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8046789/
https://www.ncbi.nlm.nih.gov/pubmed/33854040
http://dx.doi.org/10.1038/s41419-021-03688-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8046789/
https://www.ncbi.nlm.nih.gov/pubmed/33854040
http://dx.doi.org/10.1038/s41419-021-03688-7

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