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The ubiquitin ligase NEDD4-2/NEDD4L regulates both sodium homeostasis and fibrotic signaling to prevent end-stage renal disease
Kidney disease progression can be affected by Na(+) abundance. A key regulator of Na(+) homeostasis is the ubiquitin ligase NEDD4-2 and its deficiency leads to increased Na(+) transport activity and salt-sensitive progressive kidney damage. However, the mechanisms responsible for high Na(+) induced...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8046789/ https://www.ncbi.nlm.nih.gov/pubmed/33854040 http://dx.doi.org/10.1038/s41419-021-03688-7 |