Sirt1 deacetylates and stabilizes p62 to promote hepato-carcinogenesis

p62/SQSTM1 is frequently up-regulated in many cancers including hepatocellular carcinoma. Highly expressed p62 promotes hepato-carcinogenesis by activating many signaling pathways including Nrf2, mTORC1, and NFκB signaling. However, the underlying mechanism for p62 up-regulation in hepatocellular ca...

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Detalles Bibliográficos
Autores principales: Feng, Lifeng, Chen, Miaoqin, Li, Yiling, Li, Muchun, Hu, Shiman, Zhou, Bingluo, Zhu, Liyuan, Yu, Lei, Zhou, Qiyin, Tan, Linghui, An, Huimin, Wang, Xian, Jin, Hongchuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8046979/
https://www.ncbi.nlm.nih.gov/pubmed/33854041
http://dx.doi.org/10.1038/s41419-021-03666-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8046979/
https://www.ncbi.nlm.nih.gov/pubmed/33854041
http://dx.doi.org/10.1038/s41419-021-03666-z

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